In cases of a Bb infection, antibacterial therapy is indicated even if signs are relatively mild because it can not be excluded that bordetella might colonize the lower respiratory tract. If possible this should be based on results of antibiotic sensitivity. However, this is not likely to be available in all cases.
Where sensitivity is not available, almost all isolates of Bb from cats are sensitive to tetracyclines. Doxycycline is the antimicrobial of choice for treating Bb infections. Feline isolates of Bb are less susceptible to clavulanate-potentiated amoxycillin (CPA) and a high level of resistance has been detected to ampicillin and trimethoprim [Speakman et al., 1997]. Whilst antimicrobial therapy should help alleviate clinical disease, short courses of antibiotics in clinically recovered carrier cats may have little effect on shedding [Coutts et al., 1996].
Cats severly affectd by Bb require supportive therapy and intensive nursing care. The resolution of dehydration and restoration of electrolyte and acid-base disturbances preferably by intravenous fluid administration may be required.